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In the modern medical and biological research fields, the collection, transportation, and storage of biological samples are of utmost importance as they directly impact the accuracy and reliability of subsequent analyses. Among the various types of sample collection tools, the NAT tube stands out as a highly useful and versatile product.
The NAT tube is designed with multiple functions and is widely employed in the collection, transportation, and storage of venous blood samples. It also plays a crucial role in sample treatment before analysis. This tube has found its place in numerous medical and research scenarios.
In the clinical setting, the NAT tube is mainly used for the inspection of nucleic acid amplification. Specifically, it is applied to detect the DNA of the Hepatitis B virus (HBV), the RNA of the Hepatitis C virus (HCV), and the Human Immunodeficiency Virus (HIV). These viral infections pose significant threats to human health, and early and accurate detection is essential for timely treatment and disease control.
The additive in the NAT tube is a combination of EDTA.K2 and a gel separator. This unique combination is carefully formulated to meet the specific requirements of nucleic acid testing. EDTA.K2 is a well - known anticoagulant. It has the remarkable property of not affecting the activity of Taq enzyme in nucleic acid tests. Taq enzyme is a key enzyme in polymerase chain reaction (PCR), a widely used technique for nucleic acid amplification. Any interference with its activity could lead to inaccurate test results. By using EDTA.K2 as an additive, the NAT tube ensures that the enzymatic reactions in nucleic acid testing can proceed smoothly.
The gel separator in the tube also has an important function. During nucleic acid inspection, the hemoglobin in erythrocytes can cause interference in the test results. The gel separator effectively eliminates this interference. When the blood sample is centrifuged, the gel separator forms a physical barrier between the plasma and the cellular components, preventing the hemoglobin from contaminating the plasma where the nucleic acid is located.
To ensure the quality and safety of the NAT tube, it is sterilized by irradiation radiation. This sterilization method is highly effective in eliminating DNAse, RNAse, and pyrogens. DNAse and RNAse are enzymes that can degrade DNA and RNA respectively. If they are present in the tube, they can destroy the nucleic acid samples, rendering the test results invalid. Pyrogens are substances that can cause fever and other adverse reactions in the human body. By eliminating these harmful substances, the irradiated - sterilized NAT tube provides a clean and reliable environment for sample collection and storage.
Moreover, the samples separated by the NAT tube have good storage properties. They can be stored at - 70˚C. This low - temperature storage condition helps to preserve the integrity and stability of the nucleic acid samples for an extended period. It allows for long - term archiving of samples, which is beneficial for retrospective studies and follow - up analyses.
In the modern medical and biological research fields, the collection, transportation, and storage of biological samples are of utmost importance as they directly impact the accuracy and reliability of subsequent analyses. Among the various types of sample collection tools, the NAT tube stands out as a highly useful and versatile product.
The NAT tube is designed with multiple functions and is widely employed in the collection, transportation, and storage of venous blood samples. It also plays a crucial role in sample treatment before analysis. This tube has found its place in numerous medical and research scenarios.
In the clinical setting, the NAT tube is mainly used for the inspection of nucleic acid amplification. Specifically, it is applied to detect the DNA of the Hepatitis B virus (HBV), the RNA of the Hepatitis C virus (HCV), and the Human Immunodeficiency Virus (HIV). These viral infections pose significant threats to human health, and early and accurate detection is essential for timely treatment and disease control.
The additive in the NAT tube is a combination of EDTA.K2 and a gel separator. This unique combination is carefully formulated to meet the specific requirements of nucleic acid testing. EDTA.K2 is a well - known anticoagulant. It has the remarkable property of not affecting the activity of Taq enzyme in nucleic acid tests. Taq enzyme is a key enzyme in polymerase chain reaction (PCR), a widely used technique for nucleic acid amplification. Any interference with its activity could lead to inaccurate test results. By using EDTA.K2 as an additive, the NAT tube ensures that the enzymatic reactions in nucleic acid testing can proceed smoothly.
The gel separator in the tube also has an important function. During nucleic acid inspection, the hemoglobin in erythrocytes can cause interference in the test results. The gel separator effectively eliminates this interference. When the blood sample is centrifuged, the gel separator forms a physical barrier between the plasma and the cellular components, preventing the hemoglobin from contaminating the plasma where the nucleic acid is located.
To ensure the quality and safety of the NAT tube, it is sterilized by irradiation radiation. This sterilization method is highly effective in eliminating DNAse, RNAse, and pyrogens. DNAse and RNAse are enzymes that can degrade DNA and RNA respectively. If they are present in the tube, they can destroy the nucleic acid samples, rendering the test results invalid. Pyrogens are substances that can cause fever and other adverse reactions in the human body. By eliminating these harmful substances, the irradiated - sterilized NAT tube provides a clean and reliable environment for sample collection and storage.
Moreover, the samples separated by the NAT tube have good storage properties. They can be stored at - 70˚C. This low - temperature storage condition helps to preserve the integrity and stability of the nucleic acid samples for an extended period. It allows for long - term archiving of samples, which is beneficial for retrospective studies and follow - up analyses.
